However, it is important to note that our data do not allow us to exclude that other previously reported peripheral or central PPARα-mediated mechanisms, proposed to mediate for example the action of the other oleic acid-derived endocannabinoid-like compound, OEA, such as the inhibition of intestinal fat adsorption, adipogenesis and insulin resistance, and the enhancement of satiety and energy expenditure, may mediate the anti-obesity effects of OlAla and OlGly62–65. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.