The top 20 KEGG pathways in the high ANXA1 group included several cell adhesion and immune associated pathway, such as those involved in ECM receptor interaction, focal adhesion, primary immunodeficiency, hematopoietic cell lineage, toll like receptor signaling, cytokine-receptor interactions, leukocyte transendothelial migration, cell adhesion molecules, T cell receptor signaling and JAK-STAT signaling. This evidence concerns the gene ANXA1 and inborn error of immunity.