These findings indicate that aggregated tau activates the ASC inflammasome via the NLRP3-ASC axis, which exacerbates exogenously seeded and non-exogenously seeded tau pathology in vivo.399 The mechanism of action of inflammasomes may be partly because inflammasome activation produces pro-inflammatory cytokines IL-1β and IL-18,298 which have been shown to increase the tau hyperphosphorylation and accumulation.400,401 The findings highlight that the NLRP3 inflammasome may be a therapeutic target in PSP and other tauopathies. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.