MAPT and supranuclear palsy, progressive, 1: For example, according to fluorodeoxyglucose (FDG) and [11C]PK 11195 PET imaging, a CBD patient with left-sided symptoms showed a marked right hemispheric hypometabolism as well as asymmetric microglial activation in corresponding areas of the right temporal and parietal cortex and basal ganglia.408 Although both CBD and PSP belong to tauopathies, the exact pathogenesis remains unclear as to why the regions of pathological tau deposition are different and microglial roles in different tauopathies are also unknown.