Similar to PSP, increased microglial activation was also found in CBD brains compared with controls, and that microglial activation in most regions correlated with tau burden.374 Although both PSP and CBD brains showed microglial activation, a distinctive pattern of microglial activation and tau pathology was found in CBD and PSP, with CBD showing more pathology in supratentorial structures. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.