TSPO and supranuclear palsy, progressive, 1: In comparison, PSP showed more pathology in infratentorial structures.374 Another difference was that only CBD patients demonstrated increased TSPO uptake in additional motor and supplementary motor areas377 even though significantly increased mean [11C](R)PK11195 binding was observed in subcortical brain regions,377,407 especially in the medial pallidus377 in both CBD and PSP patients.