Firstly, microglial activation colocalized and correlated with tau pathology in PSP patients374,378 and transgenic mice expressing mutant tau P301L.380 Secondly, to clarify the temporal sequence of microglial activation and tauopathy, a study used Thy1-hTau.P301S mice that expressed human tau with a P301S mutation, specifically in neurons. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.