It has been shown that soluble mHTT activate IκB Kinase (IKK), triggering the NF-kB signaling pathway,446 and leads to the increase in the gene expression of pro-inflammatory cytokines.447,448 Furthermore, the reduction of mHTT levels with siRNA improved NF-kB transcriptional dysregulation and reduced pro-inflammatory cytokine production in HD.449. This evidence concerns the gene NFKB1 and Huntington disease.