For example, LC3-associated endocytosis (LANDO) in microglia facilitates Aβ receptor recycling, increasing Aβ surface receptors, thus promoting Aβ clearance, and in contrast, LANDO-deficient AD mice induced neurodegeneration and memory deficits.146 With aging, the Nogo receptor (NgR) expression on microglia increased, impairing microglial phagocytosis and clearance of Aβ. This evidence concerns the gene RTN4R and Alzheimer disease.