Importantly, TSPO is more suitable as a biomarker of neuroinflammation than a marker of microglial activation.131 However, many studies have used TSPO-PET imaging to detect microglial activation in a diverse range of neurodegenerative diseases.132 Consistent evidence using PET imaging indicated microglial activation in the brains of AD patients. The gene discussed is TSPO; the disease is Alzheimer disease.