LRRK2 and Parkinson disease: These findings highlight the importance of considering cell type when studying the impact of non-coding genetic variants on disease pathogenesis and provide mechanistic insight into the association between the 5’ region of LRRK2 and PD risk.261 Furthermore, inhibition of LRRK2 kinase activity can lead to the phosphorylation of NF-κB inhibitory subunit p50 at the protein kinase A (PKA) -specific phosphorylation site S337.