MAPT and Alzheimer disease: These reactive microglia were found to be clustered near Aβ plaques in various brain regions of AD mice and human postmortems.11,12 The in vivo imaging study also found that microglial activation correlated with tau and amyloid in AD.143 In recent years, with the development of scRNA-seq and snRNAseq technologies, microglia in various states were identified, significantly advancing our knowledge of microglia responses to pathological hallmarks in AD.