Furthermore, a recent study has demonstrated that RUNX1 is a component of the NCoR-HDAC3 complex in t(8;21) AML and collaboratively represses RUNX1-RUNX1T1-dependent transcription, thereby linking HDAC3 directly to leukemogenesis associated with t(8;21)68. This evidence concerns the gene HDAC3 and acute myeloid leukemia.