We found that genome editing of ERG resulted in the loss of leukemia cell growth accompanied by elevated apoptosis in the case of SKNO1 (AML harboring the RUNX1-RUNX1T1 translocation) and TF1 (erythroleukemia) cells, while THP1 cells were not affected by the ERG inactivation (Fig. 8B, C and Fig. S12B). Here, RUNX1T1 is linked to acute myeloid leukemia.