This enhancer contains binding motifs for multiple transcription factors, including ERG itself (heptad of transcription factors—SCL/TAL1, LMO2, LYL1, ERG, FLI1, RUNX1, GATA2), and its activation is highly correlated to the expression of ERG in human AML samples30. Here, LYL1 is linked to acute myeloid leukemia.