SLC7A11 and cancer: Recent studies showed that low-concentration paclitaxel (PTX, a mitotic chemotherapeutic drug) suppressed cancer cell proliferation by promoting the production of lactate and changing the pH of the tumor microenvironment by downregulating glutaminolysis-related genes such as GLS, SLC7A11, and SLC1A5. 237,238 In addition, low-dose PTX was shown to trigger ferroptosis by decreasing SLC7A11 expression by upregulating the well-characterized transcription factor p53(ref. 238).