Recent studies have shown that AUR has therapeutic potential for other diseases and conditions such as cancer, metabolic disease, and infectious and inflammatory diseases.186 Indeed, we provided the first report that AUR can be used in vivo as to induce ferroptosis in mice by suppressing the activity of thioredoxin reductase,22 providing compelling evidence supporting its further clinical testing—either alone or combined with other therapies—for treating ferroptosis-resistant disease conditions such as cancer. This evidence concerns the gene PRDX5 and cancer.