SRF and neoplasm: On the other hand, several studies found that combination therapies can increase SRF’s anti-tumor activity,177,178 as well as GSH starvation‒based nanoscience for cancer therapy.179,180 Notably, however, Zheng et al. recently reported that SRF failed to increase ferroptosis in various cancer cell lines.181 Thus, the precise role of SRF in ferroptosis, and its clinical value in the context of cancer, remains controversial and poorly understood.