On the other hand, Fang et al. recently identified the diphenylbutene derivative compound 3f as a ferroptosis inhibitor, and they showed that this compound can protect against ischemic stroke in rats by increasing FSP1 protein levels,233 suggesting that novel agents that upregulate FSP1 may be used to treat ferroptosis-related diseases. This evidence concerns the gene AIFM2 and ischemic stroke.