HMOX1 and cardiomyopathy: Together, these reports support the notion that HMOX1 expression has a dose-dependent differential role.140 Targeting HO-1 has been proposed as a viable strategy for treating many diseases and conditions, including cardiovascular disease3 and inflammation.141 Notably, we previously showed that inhibiting HO-1 prevents ferroptosis-induced cardiomyopathy in mice.3 To date, many HO-1 agonists and antagonists have been proposed for use in various disease models.