MAPT and Alzheimer disease: With respect to AD, several studies have shown that dysregulated iron metabolism is linked to ROS production, mitochondrial dysfunction, and neurodegeneration.42 Iron deposition in the brain, accompanied by a decrease in endogenous antioxidant capacity, has been associated with the pathogenesis of AD, and iron levels in the brain have been correlated with disease progression.49 Furthermore, accumulated iron interacts with the Aβ peptide and tau protein via the formation of a peptide-hemin complex, possibly implicating ferroptosis.50