The first is a carboxyl-modified polystyrene nanoparticle (CPS) that effectively inhibits ferroptosis by reducing cellular ROS mediated by TFEB (transcription factor EB).330 The second is DEF-HCC-PEG, a deferoxamine-binding nanoparticle that protects cells against both ferroptosis and senescence.331 Importantly, ferroptosis is a rapidly developing field, with new mechanisms underlying ferroptosis being identified; thus, additional studies are clearly helpful for accelerating the development of clinical applications using nanoparticles to target ferroptosis. The gene discussed is TFEB; the disease is hepatocellular carcinoma.