ALOX15 was recently reported to play an essential role in exacerbating I/R-induced cerebral injury259 and ischemia-induced myocardial injury260 by driving the peroxidation of PL-PUFAs and inducing ferroptosis, providing compelling evidence supporting the viability of targeting ALOX15 to treat I/R-induced injury in these tissues. Here, ALOX15 is linked to ischemia.