GPX4 and ulcerative colitis: Recently, Wang et al. reported that curculigoside inhibits ferroptosis in IEC-6 cells (a cell line used to model intestinal iron transport) by upregulating GPX4 expression.220 In mice with dextran sulfate sodium (DSS)‒induced ulcerative colitis, curculigoside was shown to protect against disease progression by reducing ferroptosis via GPX4 induction,220 suggesting that activating GPX4 is a viable therapeutic option for ulcerative colitis.