CXXC1 and cancer: We screened the differentially expressed genes (DEGs) of CFP1-knockdown versus control cells, and the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that DEGs were primarily enriched to multiple cancer initiation and progression pathways, including Ras protein signal transduction, cell adhesion, AMPK and TNF signaling pathways (Fig. 3b, c).