We conducted enrichment analysis to identify the biological functions of these H3K4me3 differentially modified genes and found that they were mostly associated with oncogenic signalings, such as Hippo, TGF-β, MAPK, NF-κB signaling pathways, as well as cancer immunity regulatory pathways IL-17 signaling and the innate immunity pathway RIG-I like-R (Fig. 5f, g). Here, TGFB1 is linked to cancer.