ANKRD22 and cancer: The downregulated genes, such as FAM83A, SCHL, and ANKRD22 were previously reported to promote cancer progression,22–25 by contrast, the upregulated genes including GAB3,26 SLC8A1,27 KCNMA1,28 and ZNF471,29 were identified as cancer-inhibiting genes in various cancer types, and negatively correlated with poor prognosis of patients.