Consistent with the enrichment analysis of cell line transcriptome data, the GSEA HALLMARK and GSVA analyses indicated that patient samples with high CFP1 expression were linked to cancer-associated pathways, such as cell proliferation, DNA replication, MYC-, KRAS-, mTOR-targeted signaling, DNA damage repair, and p53 signaling pathway (Fig. 3d, e). This evidence concerns the gene CXXC1 and cancer.