SETD1A is also reported to play a tumor-promoting role in gastric cancer.9 The non-catalytic subunits like WDR5 also had been reported to engage in the cancer process.10 CFP1 is indispensable for H3K4 trimethylation, and CSP40 deficiency (CFP1 yeast homolog) in yeast will lead to a global loss of H3K4me3.11 However, the knowledge of how CFP1 plays in cancer is absent. Here, SETD1A is linked to cancer.