MR analysis uncovered five proteins (KDELC2, SPINT2, TNFRSF10B, GSTP1, and CTSS) associated with PCa, five proteins (CPNE1, PDIA3, GDI2, ISLR2, and CTSF) linked with BRCa, and three proteins (SFTPB, ICAM5, and FLRT3) related to LCa. This evidence concerns the gene GDI2 and Leber congenital amaurosis.