These include tiers 3 targets for PCa such as SPINT2, GSTP1, and CTSS, tier 3 target (GDI2) for BRCa, and tiers 4 targets (ISLR2 and CTSF) for BRCa, tier 3 target (SFTPB) and tier 4 targers (ICAM5, and FLRT3) for LCa. This evidence concerns the gene ISLR2 and posterior cortical atrophy.