The resulting PPI network exposed interactions between two causative proteins (TNFRSF10B, GSTP1) and the targets of four drugs currently used in PCa treatment, of which TNFRESF10B-CASP8, GSTP1-CYP17A1, and GSTP1-AR were considered strong interactions (Additional file 1: Fig. S4A). The gene discussed is TNFRSF10B; the disease is posterior cortical atrophy.