During the external validation stage, four out of the five proteins associated with PCa (KDELC2, SPINT2, TNFRSF10B, and CTSS) and three out of the five proteins linked with BCa (CPNE1, PDIA3, and GDI2) were successfully replicated using similar approaches in the UK Biobank, further bolstering the reliability of the potential drug targets identified in this study. Here, SPINT2 is linked to posterior cortical atrophy.