Among the candidates described (Fig. 2B and Supplementary Fig. 2D-F), classification tree analysis revealed that three heterogeneous expression of doublecortin (DCX) and EGFR genes, the former associated with neurodevelopmental and progenitor cell signatures and the latter with stemness [20, 49–52], almost perfectly segregated GBM patients. The gene discussed is EGFR; the disease is glioblastoma.