Our results also showed significant differences in the expression of immune checkpoints, immune cell markers, and tumor metabolic markers in high and low m6Ascore groups, such as CCL2, CD8A, CD68, CTLA4, HAVCR2, and PDCD1LG2 were highly expressed in the high m6Ascore group, while two immune checkpoints, CD276 and PDCD1, were highly expressed in the low m6Ascore group (Fig. 10). This evidence concerns the gene PDCD1LG2 and neoplasm.