AKT1 and glioblastoma: For example, METTL3 can accelerate the metastasis and radiation resistance of Glioblastoma by enhancing the stability of SOX2. For example, METTL3 can accelerate the metastasis and radiation resistance of Glioblastoma by enhancing the stability of SOX2 leading to malignant events [35]; decreased m6A methylation attenuates the expression of the AKT negative regulator PHLPP2, while increasing the expression of the AKT positive regulator mTORC2 [36].