GPX4 and colorectal carcinoma: To determine whether ferroptosis played a role in the therapeutic impact of curdione in CRC mice, qPCR was adopted to assess the mRNA levels of METTL3, METTL4, METTL14, SLC3A2, SLC7A11, HOXA13, YTHDF2, GPX4, and PTGS2 in the tissues of four groups of CRC mice, as shown in Fig. 6.