RGS1 and nonpapillary renal cell carcinoma: As indicated by the results of the KEGG enrichment study (Fig. 3D, E), DEGs were primarily enriched in the production of immunoglobulin and B-cell activation, two biological mediators of immunological response, and the enriched differentially expressed genes (DEGs) took on critical significance to in TME and immune infiltration in ccRCC, suggesting the important and complex role of RGS1 in TME.