HRAS and head and neck squamous cell carcinoma: HNSCC with HRAS mutations shows poor clinical outcomes with a high recurrence rate following primary definitive treatment (50–67% recurrence within 6 months), short disease-free survival (4.0 months; 95% CI 1.0 to 36.0), and overall survival (15.0 months; 95% CI 6.0 to 52.0) [33].