The cerebrospinal fluid (CSF) level of sVCAM1 was inversely correlated with microglial infiltration into Aβ plaques in the brains of patients with AD (Fig. 6d,e and Extended Data Fig. 6c–e); moreover, this inverse correlation was independent of APOE4 genotype (Fig. 6f). This evidence concerns the gene APOE and Alzheimer disease.