PPP1CB and metabolic dysfunction-associated steatohepatitis: For the NASH model, liver WDR6 was increased in mice with a HFHC diet, along with the pathological progression of NASH, in the 2- to 16-week time period of feeding, and that phospho-PPP1CB (Thr316) was, as expected, decreased (Extended Data Fig. 10a,b).