FAT4 and diabetes mellitus: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that FAT4-co-expressed genes were primarily involved in focal adhesion, extracellular matrix (ECM)-receptor interactions, platelet activation, axon guidance, the Rap1 signaling pathway, vascular smooth muscle contraction, the AGE-RAGE signaling pathway in diabetes, arrhythmogenic right ventricular cardiomyopathy, the Ras signaling pathway, and lipolysis regulation in adipocytes (Fig. 3d).