On investigating the function of FAT4 in HCC, we found that FAT4 was primarily involved in biological processes related to cell motility and that FAT4 expression was significantly positively correlated with the PI3K/AKT/mTOR pathway, ECM degradation, transforming growth factor β, ECM-related genes, and IL-10 anti-inflammatory signaling pathway in HCC. The gene discussed is FAT4; the disease is hepatocellular carcinoma.