SH3PXD2A and pulmonary fibrosis: To genetically dissect the likely role of Tks5 in pulmonary fibrosis, BLM was administered to 8-10-week-old C57Bl6/J Tks5+/- mice and WT littermates (Fig. 4a, b), which were sacrificed 14 days post BLM (at the peak of the disease in the local settings), as previously described24.