SH3PXD2A and pulmonary fibrosis: Therefore, in this report we investigated a possible role of TKS5 and podosomes in the pathogenesis of pulmonary fibrosis employing in silico analysis of publicly available human and mouse transcriptomic datasets, de novo analysis of human samples and associated clinical data, disease modeling in mice, ex vivo/in vitro human/mouse cell cultures and dedicated functional assays, as well as pharmacologic validation experiments.