COL1A1 and Bloom syndrome: Vice versa, culture of primary NMLFs on Col1a1-rich aECM prepared from the lungs of mice post BLM (Supplementary Fig. 9c), stimulated Tks5 expression (Fig. 6d, e) and the formation of podosomes (Fig. 6f), and further stimulated Col1a1 expression (Fig. 6g), indicating an ECM-podosome cross talk in the perpetuation of LF activation.