MAPT and supranuclear palsy, progressive, 1: The motor phenotype is in line with motor dysfunction in progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), argyrophilic grain disease (AGD), Pick’s disease (PD) in which tauopathy is the major pathological feature.4,5 Thus, although abnormally accumulated or overexpressed Tau can participate in many aspects of cellular dysfunction to cause diverse phenotypes, its high level is more likely to severely affect neuronal function related to body movement and motor activity.