Remarkably reduced MSU uptake is observed in CD14 knockout mice.14 Membrane-bound CD14 (mCD14) and soluble CD14 (sCD14) cooperate with Toll-like receptors (TLRs) to facilitate innate immune responses.15 We found that mCD14 expression on peripheral blood mononuclear cells is significantly reduced in patients with gout. This evidence concerns the gene CD14 and gout.