In human pancreatic cancer, MAP4K1 loss is associated with the development of invasive pancreatic ductal adenocarcinomas, and its restoration in pancreatic ductal adenocarcinoma cells inhibits cell proliferation (Wang et al, 2009) and reduces invasion potential by inducing degradation of oncogenic kinase AXL (Song et al, 2020). The gene discussed is MAP4K1; the disease is pancreatic ductal adenocarcinoma.