AKT1 and glioblastoma: To test how MAP4K1 regulates the IL-18R and IL-6R signaling pathways in GBM cells, we examined the phosphorylation (activation) of AKT on serine 473 (P-AKT) and found that P-AKT was blocked after MAP4K1-KD (Fig S5A), whereas MAP4K1 restoration rescued P-AKT levels (Fig S5B).