Moreover, CGGA data (batch 2 and batch 1) showed that the levels of MAP4K1 mRNA in GBM were higher than those in low-grade gliomas (Fig 2C and D), and the percentage of high MAP4K1 mRNA level cases increased with the grades of gliomas (Fig 2E and F), supporting a positive correlation of MAP4K1 levels with a malignant phenotype of gliomas. The gene discussed is MAP4K1; the disease is central nervous system cancer.