In line with our previous findings (Figures 5A and S4A), we observed that PB alone generally did not significantly change the RNA expression level of oncogenic CRC genes, whereas treatment with RA alone or with PB + RA led to more substantial changes in expression of many CRC-associated factors, including activating expression of the retino-sympathetic CRC genes RARA, RARB, SOX4, and MEIS1 (Figure 6A),20 and we saw significant changes in H3K27ac deposition around these genes (Figure S5C). This evidence concerns the gene MEIS1 and colorectal carcinoma.