ATP7A and coronary artery disorder: For example, genetically proxied MC1-specific effect reduced CAD risk (OR = 0.65, 95% CI = 0.48–0.87, P = 0.004; Supplementary Fig. S4), BMI levels (β = −0.21, 95% CI = −0.34 to −0.08, P = 0.001; Supplementary Fig. S5) and DBP levels (β = −0.31, 95% CI = −0.42 to −0.20, P = 4.04 × 10−8), but increased SBP levels (β = 0.18, 95% CI = 0.07–0.29, P = 1.15 × 10−3), which suggested the possibility of conflicting effects of the same metformin target on different outcomes.