Notably, the EZH2 CR mutant had a gain-of-function phenotype, giving significantly better rescue than that of WT EZH2 (P < 0.01) and phenotypically mimicking a gain-of-function mutant (EZH2 Y646F) that is well-studied in the human system and frequently found in lymphoma (Fig. 5B) (46-48). This evidence concerns the gene EZH2 and lymphoma.