Recent studies have shown that Ly6Chi monocytes surround S. Typhimurium-confining granulomas in the spleen and recruit CD4+ T cells to the foci of infection by producing CXCL9 and CXCL10, both are ligands for CXCR3 expressed by Th1 cells [58]. The gene discussed is CXCR3; the disease is infection.