Among the genes that are involved in the pathway between PAMP sensors and Ifnb1 transcription, ISGs such as Tlr3, Ddx58 (coding for RIG-I sensor) or Irf7 were not induced upon infection in CC071, while constitutively expressed genes such as Mavs, Ticam1 (coding for the TRIF adaptor), Traf3 or Irf3, showed comparable levels of expression in the three strains (S3B Fig). Here, TLR3 is linked to infection.