Further, MPPED2 is downregulated in glioblastoma [17] and thyroid neoplasia [18], acts as a tumor suppressor in breast cancer [19] and oral squamous cell carcinoma [20], and the MPPED2 gene is differentially methylated in colorectal cancer [21] and in individuals with gender incongruence [22]. The gene discussed is MPPED2; the disease is oral cavity squamous cell carcinoma.