Further, MPPED2 is downregulated in glioblastoma [17] and thyroid neoplasia [18], acts as a tumor suppressor in breast cancer [19] and oral squamous cell carcinoma [20], and the MPPED2 gene is differentially methylated in colorectal cancer [21] and in individuals with gender incongruence [22]. Here, MPPED2 is linked to colorectal cancer.