FBN1 and Sotos syndrome: These results were nominally significant (P < 0.05) when limiting our analysis to 3 genes in which variants have previously been described as causal for some of the most prevalent syndromes associated with tall stature, specifically Marfan syndrome (FBN1) [6–8], Weaver syndrome (EZH2) [9], and Sotos syndrome (NDS1) [10] (OR = 43.7 [95% CI 1.06, 271], P = 0.024).