Mutations or dysregulated expression of lncRNAs like POP1-1 [75], EGFR-AS1 [76], GAS5 [77], BARX1-DT, KLHL7-DT, and LINC02154 [78], seem to be associated with response to different types of therapies, such as chemotherapy, chemoradiotherapy, and immunotherapy in patients with HNSCC. The gene discussed is POP1; the disease is head and neck squamous cell carcinoma.