Modulation of many signaling pathways in HNSCC has been found to be related to lncRNAs, including but not limited to Wnt/β-catenin, PI3K/AKT/mTOR, JAK/STST3, p53, NF-B, TGF-β/Smad, and Notch [85–88]. This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.