Mutations or dysregulated expression of lncRNAs like POP1-1 [75], EGFR-AS1 [76], GAS5 [77], BARX1-DT, KLHL7-DT, and LINC02154 [78], seem to be associated with response to different types of therapies, such as chemotherapy, chemoradiotherapy, and immunotherapy in patients with HNSCC. This evidence concerns the gene KLHL7 and head and neck squamous cell carcinoma.