In light of experimental evidence that Calculus Bovis, a traditional Chinese medicine, could alleviate liver injury and up-regulate the expression of MRP2 in 17α-ethynylestradiol-induced cholestasis by a mechanism involving inhibition of the Akt signaling pathway [13], it is conceivable that MRP2 is induced following menthol exposure. The gene discussed is ABCC2; the disease is cholestasis.