To further determine the role of GLUT2 in the activation of SCO cell secretion in response to hyperglycemia, we inactivated GLUT2 by injecting AAV-GFAP-Cre-GFP or AAV-GFAP-GFP into the SCO of GLUT2loxp/loxp mice (control, blood glycemia = 8.6 ± 0.3 mM, N = 6) and performed analyses under hyperglycemic conditions. Here, SLC2A2 is linked to Hyperglycemia.