CTNNB1 and neoplasm: For other parameters, such as metastasis (Supplementary Figure 1), vascular invasion (Supplementary Figure 2), and tumor size (Supplementary Figure 3), of HCC showing CTNNB1 mutation, the pooled ORs were1.25(n=4studies, 95%CI:0.93-1.66, Z=1.49, P=0.14),1.42 (n=3 studies, 95%CI:0.82-2.45, Z=1.26, P=0.21) and 1.24 (n=5 studies, 95%CI:0.37-4.11, Z=0.35, P=0.72), respectively, demonstrating that CTNNB1 mutation had no significant correlation with these parameters.