The present study demonstrate that PF exerts reno-protective effects in animal models of DN by promoting antioxidant effects, inhibiting macrophage infiltration activation, suppressing inflammatory responses, reducing mesangial cell proliferation, inhibiting endothelial proliferation, attenuating mesangial expansion and tubulointerstitial injury, and inhibiting TLR2 / 4 signaling pathway activation. This evidence concerns the gene TLR2 and liver dysplastic nodule.