IFNA1 and systemic lupus erythematosus: Our in vitro studies verified the sizeable contribution of XIST-derived TLR7 ligands to TLR7 signaling and IFN-α production by pDCs, findings that were mirrored in kidney-infiltrating and peripheral blood leukocytes from women with SLE, in which XIST RNA levels were correlated with the IFN signature and disease activity, respectively.