Therefore, to evaluate the effect of systemic inhibition of RFX1 on autoimmunity, the administration of ADP in an SLE mouse model will be used to evaluate the effects of RFX1 inhibition on macrophage polarization and Th17 differentiation in vivo as well as the ultimate impact on the development of SLE. This evidence concerns the gene RFX1 and systemic lupus erythematosus.