Compared with HCs, the methylation levels in the promoter of TNF in CD14+ monocytes from patients with SLE were significantly decreased (Figure 8E and Supplemental Figure 10B), but the mean methylation level of the IL6 promoter had a decreased tendency in CD14+ monocytes from patients with SLE (Figure 8F and Supplemental Figure 10C). This evidence concerns the gene IL6 and systemic lupus erythematosus.