Accumulating evidence has also uncovered that the abnormal DNA hypomethylation in autoimmune-related genes, including CD11a (ITGAL), perforin (PRF1), CD70 (TNFSF7), and CD40 ligand (TNFSF5) in T cells is a crucial hallmark in SLE (47). This evidence concerns the gene CD70 and systemic lupus erythematosus.