Besides, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the downregulated genes in CKO PMAs were enriched in multiple inflammatory signaling pathways, including IL-17A and TLR, Th17 cell differentiation, M1-related bacterial infection, and autoimmunity diseases like IBD and type 1 diabetes mellitus (Figure 3G). Here, IL17A is linked to autoimmune disease.