For example, histone 3 lys27 tri-methyltransferase Ezh2 epigenetically inhibited antiinflammatory mediator Socs3 in macrophages by mediating H3K27me3, which promoted autoimmune inflammation in DSS-induced colitis and experimental autoimmune encephalomyelitis (29). This evidence concerns the gene EZH2 and experimental autoimmune encephalomyelitis.