The general view of the origins of latently infected resting memory CD4+ T cells is that they arise from infection of CD4+ T cells activated during an immune response as the activated T cells return to an immunologically resting state (4), but in Fiebig I, prior to immune activation in response to evolving infection, we showed that target cell availability in LN tissues was essentially limited to resting CD4+ T cell populations. The gene discussed is CD4; the disease is infection.