Taking 700 grams as the total weight of LT in a 70 kg person (39), the average of approximately 300,000 HIV-producing resting CD4+ T cells translates to a population of more than 200 million HIV-producing cells immediately available to reestablish systemic infection when treatment is interrupted, which could well have contributed to viral rebound, despite initiating ART in the earliest possible stage of infection (21). The gene discussed is CD4; the disease is infection.