IFNA1 and systemic lupus erythematosus: In support of this, we found that SLE UDON clusters that map to IFN signaling (SLE-U3 and SLE-U11) (Supplemental Figure 18) in CD16 Monocytes and B Memory cells were associated with high SLE disease activity index (SLEDAI) scores, as well as in NK cells associated with kidney involvement (adjusted P < 0.1, CMH).