While HOXB3 gene involvement with the development of the craniofacial region has been previously described in mice [19], data about the HOXB3 protein presence in human tissue is relatively limited mainly discussing disruption of HOXB3 function in formation of some pathologies with altered cell proliferation like breast cancer [34] and glioblastoma [35]. The gene discussed is HOXB3; the disease is glioblastoma.