POU class 2 homeobox 2 (POU2F2) has been regarded as a B‐cell‐specific octamer TF that regulates B cell proliferation and differentiation.[11, 12, 13, 14] It was recently shown to promote solid tumors' progression and metastasis, including pancreatic cancer, gastric cancer, and breast cancer.[15, 16, 17, 18] We once determined POU2F2 expression in primary human hepatoma cells but not in primary normal human hepatocytes by RNA‐sequencing assay (data not shown), suggesting a link between POU2F2 expression and HCC. This evidence concerns the gene POU2F2 and breast carcinoma.