POU2F2 and hepatocellular carcinoma: To validate our prediction, the promoter‐reporter strategy was used to isolate GFP+ or GFP− hepatocytes (namely POU2F2+ or POU2F2− hepatocytes) from DEN‐challenged mice at months 5 and 6 when HCC had not been induced or at month 7 when HCC had been induced (Figure 2A).