Fructus Lycii, an ingredient of KLX, can improve renal function and delay the progression of DKD by inhibiting the expression of NF-κB.41 Another ingredient of KLX, rhubarb, can inhibit renal fibrosis, promote toxin excretion, improve early symptoms of chronic renal insufficiency, and delay renal failure.42 These studies suggest that KLX capsules may have an effect on improving renal function, and more evidence-based medical findings are required through prolonging the research cycle, increasing the sample size, and/or increasing the therapeutic dose of irbesartan. This evidence concerns the gene NFKB1 and diabetic kidney disease.