APOE and neoplasm: Several genes related to tumor cell differentiation were identified: CYR61, SERPINA1, TIMP1, FN1, S100A6, APOE, and APOC1. Studies have confirmed the prognostic values of CYR61 (Ren et al. 2021), SERPINA1 (Wu et al. 2021), and FN1 in THCA.