The probability of interaction between tumor cells and fibroblast receptor-ligand pairs was higher than that of thyroid cells, especially in TGFB1/ACVR1/TGFBR1, FGF18/FGFR1, BTC/EGFR, BMP8A/BMPR1A/BMPR2, and BMP8A/BMPR1A/BMPR2 (Fig. 5D). The gene discussed is ACVR1; the disease is neoplasm.