Ligand–receptor pairs, such as PROS1-AXL, NAMPT-INSR, MDK-LRP1, MDK-ALK, GAS6-MERTK, and GAS6-AXL, between endothelial and tumor cells exhibited a higher communication possibility than that between endothelial cells and thyrocytes (Fig. 5B). This evidence concerns the gene MDK and neoplasm.