Although the evidence available today is still sparse, recent data unravelled a potential role of FGFR2 on neurodevelopment, such as the reported presumed loss-of-function mutation (c.A1295G) of FGFR2 in an autistic child, without features of craniosynostosis (Tammimies et al., 2015). This evidence concerns the gene FGFR2 and craniosynostosis.