FGFR2 and hypospadias: However, FGFR2 is nearly ubiquitously expressed, particularly in the brain, respiratory system, male and female tissues, and skin (Fig. 2); thus, mutations in this gene have been associated with other clinical phenotypes, such as Hypospadias and Lacrimo-auriculo-dento-digital syndrome (Azoury et al., 2017; Stenson et al., 2020).