FGFR2 has been associated with several heterogeneous autosomal-dominant syndromes, among which the Pfeiffer (#MIM 101600), Crouzon (#MIM 123500), Apert (#MIM 101200) syndromes, variably presenting overlapping features affecting the skin and the skeletal and neurological systems, and often associated with a high risk of cancer. Here, FGFR2 is linked to cancer.