Therefore, it is not surprising that most FGFR2 pathogenic variants (mainly missense ones) lead to syndromic craniosynostosis (i.e., Crouzon, Apert, Pfeiffer, Beare-Stevenson cutis gyrate, Jackson-Weiss, and Seathre-Chotzen-like syndromes) with a multisystemic involvement (Azoury et al., 2017). The gene discussed is FGFR2; the disease is craniosynostosis.