LRIG1 and neoplasm: Within promoter regions, the top DEG upregulated in EA was LRRC2 (|log2FC| = 5.6, FDR = 6.2 × 10−13), a long noncoding RNA suspected to function as a tumor suppressor, followed by LRIG1, which interestingly also has an anti-invasive role in basal-like breast cancer cells through encouraging mesenchymal-to-epithelial transition (ref. 39; Table 3).