FOXO4 and cancer: AA-associated DARs were also overabundant in motifs of several TFs from the AP-2 family, including AP2A, 2B, and 2C, and multiple isoforms, which have a well-documented role in breast carcinogenesis (33); also enriched were motifs in forkhead box (FOX) TFs, including members of the FOXO4 (implicated in cancer cell invasion and replicative immortality), FOXD2 (implicated in chemoresistance), FOXI1 (associated with poor prognosis in breast cancer), and FOXL1 (modulator of Wnt signaling) subfamilies (34, 35).