Differentially accessible chromatin regions (DAR) in the AA-derived TNBC lines showed an overabundance in motifs associated with the Grainyhead family of TFs, such as GRHL1 and TFCP2, which are considered pro-oncogenic in breast cancer and involved in pro-metastatic processes like epithelial-to-mesenchymal transition and angiogenesis (32). This evidence concerns the gene GRHL1 and breast cancer.