AA-derived TNBC lines displayed strong overabundance in motifs associated with members of the Grainyhead, Forkhead Box, and AP-2 TF, which have been extensively linked to a pro-oncogenic and pro-metastatic tumor biology, notably including cancer cell invasion, epithelial-to-mesenchymal transition, angiogenesis, and poor prognosis in breast cancer. The gene discussed is TFAP2A; the disease is cancer.