KISS1R and asthma: The most prominent change was the ∼50% increase in airway-associated adipose tissue in Kiss1r KO mice; despite this substantial change in airway adiposity there was no simultaneous effect on baseline or post-bronchial challenge Raw, G or H. These data suggest that airway-associated adipose tissue expansion alone, at least up until young adulthood, does not directly impair lung function and may instead act as a contributing factor to disease severity, in much the same way as proposed interactive effects of inflammation and remodelling [14], or generalised body fat in a patient with asthma.