To verify that GPR37 mediates the progression of NSCLC via the PI3K/Akt/mTOR pathway, proteins closely related to the PI3K/Akt/mTOR pathway, such as P‐AKT1, AKT1, EIF4EBP1, P‐EIF4EBP1, P‐p70S6K, p70S6K, mTOR, P‐mTOR, PI3K, and P‐PI3K were detected. This evidence concerns the gene GPR37 and non-small cell lung carcinoma.