Patients with NASH and CHc had a higher tendency to express tumor markers of HCC, including serum AFP and PIVKA‐II, compared with those with CRC, while patients with CRC had a higher tendency to express tumor markers of CRC, including serum CEA and CA19‐9, compared with those with NASH and CHc; however, there was no significance because of the large standard errors. The gene discussed is AFP; the disease is cryohydrocytosis.