The dense staining of NRF2 in the nuclei of non‐tumor hepatocytes positively correlated with liver inflammation (CRC and NASH; R = 0.451, p < 0.001, CRC and CHc; R = 0.502, p < 0.001) and fibrosis (CRC and NASH; R = 0.566, p < 0.001, CRC and CHc; R = 0.548, p < 0.001) in both NASH and CHc, and was inversely correlated with hepatic spare ability features such as platelet count (R = −0.253, p = 0.002) and prothrombin time (R = −0.206, p = 0.012). This evidence concerns the gene F2 and cryohydrocytosis.