PALB2 and breast cancer: Fanconi anemia is also brought on by germline homozygous loss of function (LoF) mutations of PALB2, like BRCA2 (Reid et al., 2007; Xia et al., 2007), although heterozygous LoF mutations have been associated with hereditary breast cancer and pancreatic cancer (Jones et al., 2009; Antoniou et al., 2014).