According to the information that is currently available, castration-resistant PCa have an enrichment of approximately two times the frequency of localized PCa in terms of tumoral germline or somatic ATM mutations, which vary from 5% to 8% of the tumors, also Men with pathogenic ATM mutations have an increased risk of developing PCa, which may potentially cause the condition to appear earlier (Giri and Beebe-Dimmer, 2016; Thalgott et al., 2018; Wokołorczyk et al., 2020). Here, ATM is linked to posterior cortical atrophy.