BRCA1 and posterior cortical atrophy: Numerous authors have discussed the mutation spectrum in relation to PCa risk, but Ashkenazi Jewish and Icelandic populations have been found to have frameshift deletion 185delAG and a frameshift insertion 5382insC for BRCA1 and BRCA2 frameshift deletion, as well as 999del5 founder mutations linked to poor survival in young people (Wilkens et al., 1999; Tryggvadóttir et al., 2007).