This review effort focuses on the MSH2, MSH6, MLH1, and PMS2 genes (Table 1), which are more frequently found in PCa and have recently been described by Pecina et al., though previous authors have reported on other MMR genes which are also connected to high microsatellite instability and high tumor mutational load involved in PCa progression (Chen et al., 2011; Sedhom and Antonarakis, 2019; Pećina-Šlaus et al., 2020). This evidence concerns the gene MSH6 and neoplasm.