The MSH6 gene participates in MMR pathways and mutation of this gene has been associated with an increase in the likelihood of developing PCa (Pritchard et al., 2014) According to recent research, structural rearrangements such as insertions and deletions are what make MSH6 more susceptible to mutations (Dominguez-Valentin et al., 2016). This evidence concerns the gene MSH6 and posterior cortical atrophy.