Zeng et al., (2021). Proved that m6A levels and the expression of methylation-related enzymes were altered in PAH rats, playing crucial roles in PAH development (Zeng et al., 2021). In addition, one of m6A regulators, YTHDF1, has been confirmed to facilitate hypoxic PASMCs proliferation in mice. While silencing of YTHDF1 attenuated pulmonary vascular changes, pulmonary fibrosis and decreased right ventricular systolic pressure compared with PAH mice (Kang et al., 2023). The gene discussed is YTHDF1; the disease is pulmonary fibrosis.