Besides, elevated expression of FMR1 was regarded as a pathogenic target in promoting cell proliferation in esophageal squamous cell carcinoma (ESCC) (Men et al., 2022); the positive feedback loop HNF4α-BC200-FMR1 is also necessary in promoting invasive mucinous lung adenocarcinoma (IMA) progression and metastasis. This evidence concerns the gene FMR1 and esophageal squamous cell carcinoma.