Mechanistically, TRIB3 can facilitate breast cancer stem cells through regulating AKT to interfere with the FOXO1-AKT interaction and inhibit FOXO1 phosphorylation, ubiquitination, and degradation by E3 ligases SKP2 and NEDD4L (Yu et al., 2019). The gene discussed is NEDD4L; the disease is breast carcinoma.