WWP1 and non-small cell lung carcinoma: In NSCLC, TRIB3 has been found to interact with EGFR and recruits PKCα to induce a Thr654 phosphorylation and WWP1-induced Lys689 ubiquitination in the EGFR juxtamembrane region, subsequently promoting EGFR recycling, stability, downstream activity, and NSCLC stemness (Yu et al., 2020).