With regards to KEGG analysis, asthma, hematopoietic cell lineage, leishmania infection, NK cell mediated cytotoxicity and systemic lupus erythematosus were enriched downstream pathways of DEGs in normal samples, while huntingtins disease, proteasome, protein export, spliceosome and ubiquitin mediated proteolysis were potential signaling pathways modulated by DEGs in osteosarcoma samples (Figures 4B, D). Here, HTT is linked to systemic lupus erythematosus.