PPARGC1A and metabolic dysfunction-associated steatotic liver disease: Moreover, DMY has been shown to increase SIRT3 expression by activating the AMPK-PGC1α/ERRα signaling pathway, and promote the expression of mtDNA-encoded genes, restore the enzymatic activity of MRCs and increase the mtROS scavenging ability through the SIRT3-dependent mechanism, thus improving the mitochondrial respiratory capacity and redox homeostasis of hepatocyte to prevent NAFLD (57).