TROAP and telomere syndrome: At the same time, GSEA results indicate that STS patients with low TROAP expression are mainly concentrated in arachidonic acid metabolism, asthma, complement, and coagulation cascades, hematopoietic cell linage, lysosome, type I diabetes mellitus (Figure 8C), for STS patients with high TROAP expression, base excision repair, cell cycle, nucleotide excision repair, oocyte meiosis, pyrimidine metabolism, and spliceosome are their main enriched pathways (Figure 8D).