PAX7 and facioscapulohumeral muscular dystrophy: Nevertheless, Banerji and Zammit evaluated PAX7 target genes in FSHD biopsies and found an inverse correlation: genes up and downregulated by PAX7 tended to be down and upregulated, respectively, in FSHD biopsies.10 In this issue of Brain Communications, they mine this PAX7 gene set more deeply, in an attempt to explore whether a subset of these genes might serve as a useful biomarker for disease severity or progression in FSHD.11